Encapsulation of a steroid in polymer matrix of chitosan
Keywords:
polymeric matrix, chitosan microspheres, spray drying, DI-31Abstract
The DI-31, synthetic analogue of brassinoesteroids,is the active principle (AP) of 16 Biobras, bio-stimulator of plant growth that has proven positive impact on Cuban agriculture. However, it has the disvantages of low solubility in water and the speed with which plants metabolize it. One alternative to overcome these limitations is its microencapsulation into polymeric matrix. It has been investigated that the chitosan constitute an excellent candidate for microencapsulation of DI-31. Chitosan is a natural polysaccharide obtained from chitin extracted from the exoskeletons of crustaceans, that increasing the resistance of plants to attack by variour pests and promote crop yields, possesses excellent biocompatibility.biodegradability, and mucoadhesiveness inducing potential defense against attack by different pathogens.
References
Akbuga, J. (1995), A Biopolymer: Chitosan, International Journal of Pharm. Advances, vol. 1, pp. 3-18.
Berthold, A., Cremer, K. and Kreuter, J.(1996), Influence of Crosslinking on the Acid Stability and Physicochemical Properties of Chitosan Microspheres, S.T.P. Pharma Sciences, vol. 6, no. 5, pp. 358-364.
Bulgarelli, E., Forni, F. and Bernabei, M.T. (1999), Casein/Gelatin Beads:I. Cross-linked Solution Composition Effect on Cross-linking Degree, International Journal of Pharmaceutics, vol. 190, pp. 175-182.
Bhattarai N, Gunn J, Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Advanced Drug Delivery Reviews. 2010;62:83-99.
He, P., Davis, S.S. and Illum, L. (1999), Chitosan Microspheres Prepared by Spray-drying, International Journal of Pharmaceutics, vol. 187, no. 1, pp. 53-65.
Huang, Y.C., Chiang, C.H. and Yeh, M.K. (2003), Optimizing Formulation Factors in Preparing Chitosan Microparticles by Spray-drying Method, Journal of Microencapsulation, vol. 20, no. 2, pp. 247-260.
Kim, C.J. and Lee, P.I. (1992), Synthesis and Characterization of Suspension-polymerized Poly(Vinyl Alcohol) Beads with Core-Shell Structure, Journal of Applied Polymer Science, vol. 46, no. 12, pp. 2147-2157.
Ré, M.I. (1998), Microencapsulation by Spray Drying, Drying Technology, vol. 16, no. 6, pp. 1195-1236.
Vandelli, M.A., Pifferi, G., Seghizzi, R. and Cameroni, R. (1995), Swelling Behaviour of Gelatin Microspheres Crosslinked with d,l-glyceraldehyde. The Effect of the Preparative Factors, Pharmacy and Pharmacology. Letters. vol. 5, pp. 116-119.
Tewes F, Boury F, Benoit JP. Biodegradable Microspheres: Advances in Production Technology. In: Benita S, editor. Microencapsulation Methods and Industrial Applications 158. 2nd ed. USA: Taylor & Francis Group; 2006. p. 1-53.
Desai KGH, Park HJ. Preparation and Characterization of Drug-Loaded Chitosan-Tripolyphosphate Microspheres by Spray Drying. Drug Development Research. 2005;64:114-28.
Peniche C, Fernández M, Gallardo A, López-Bravo A, Román JS. Drug Delivery Systems Based on Porous Chitosan/Polyacrylic acid Microspheres. MacromolecBioscien. 2003;3:540-5.
The United States Pharmacopeia, USP 30. The National Formulary, NF 25 (USP30-NF25). The dissolution procedure: development and validation. Rockville: Mack Printing; 2007.
The United States Pharmacopeia, USP 30. The National Formulary, NF 25 (USP30-NF25). Bisacodyl Delayed-ReleaseTablets. Rockville: MackPrinting; 2007.
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